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Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling.
Svensson CI, Inoue T, Hammaker D, Fukushima A, Papa S, Franzoso G, Schett G, Corr M, Boyle DL, Firestein GS. Svensson CI, et al. Arthritis Rheum. 2009 Nov;60(11):3229-40. doi: 10.1002/art.24887. Arthritis Rheum. 2009. PMID: 19877043 Free PMC article.
Furthermore, Gadd45beta deficiency exacerbated K/BxN serum-induced arthritis in mice, dramatically increased signaling through the JNK pathway, elevated MMP3 and MMP13 gene expression in the mouse joints, and increased the synovial inflammation and number of osteoclasts. C …
Furthermore, Gadd45beta deficiency exacerbated K/BxN serum-induced arthritis in mice, dramatically increased signaling through the JNK pathw …
Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK.
Sundarrajan M, Boyle DL, Chabaud-Riou M, Hammaker D, Firestein GS. Sundarrajan M, et al. Arthritis Rheum. 2003 Sep;48(9):2450-60. doi: 10.1002/art.11228. Arthritis Rheum. 2003. PMID: 13130464 Free article.
OBJECTIVE: The mitogen-activated protein (MAP) kinase JNK is a key regulator of interleukin-1 (IL-1)-induced collagenase gene expression and joint destruction in arthritis. Two upstream kinases, MKK-4 and MKK-7, have been identified as potential activators of JNK. ...The J …
OBJECTIVE: The mitogen-activated protein (MAP) kinase JNK is a key regulator of interleukin-1 (IL-1)-induced collagenase gene expression and …
Regulation of JNK by MKK-7 in fibroblast-like synoviocytes.
Inoue T, Hammaker D, Boyle DL, Firestein GS. Inoue T, et al. Arthritis Rheum. 2006 Jul;54(7):2127-35. doi: 10.1002/art.21919. Arthritis Rheum. 2006. PMID: 16802349 Free article.
OBJECTIVE: JNK regulates matrix metalloproteinase (MMP) gene expression and joint destruction in rheumatoid arthritis (RA). Previous studies demonstrated that the 2 upstream MAPK kinases (MKK-4 and MKK-7) are phosphorylated in RA synovium and form a complex with JNK in fib …
OBJECTIVE: JNK regulates matrix metalloproteinase (MMP) gene expression and joint destruction in rheumatoid arthritis (RA). Previous …
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-terminal kinase pathway.
Lee SI, Boyle DL, Berdeja A, Firestein GS. Lee SI, et al. Arthritis Res Ther. 2012 Feb 21;14(1):R38. doi: 10.1186/ar3750. Arthritis Res Ther. 2012. PMID: 22353730 Free PMC article.
Interleukin-1beta (IL-1beta), MMP3 and MMP13 gene expression in ankle joints were decreased by MKK7 ASO (P < 0.01). CONCLUSIONS: MKK7 plays a critical regulatory role in the JNK pathway in a murine model of arthritis. ...

Interleukin-1beta (IL-1beta), MMP3 and MMP13 gene expression in ankle joints were decreased by MKK7 ASO (P < 0.01). CONCLUSIONS: M

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